| Colchester United FC v West Ham United (U21`s) 28/09/2021 | £7.50 | |
| Manchester United FC v Villarreal CF 29/09/2021 | £7.50 | |
| Luton Town FC v Coventry City FC 29/09/2021 | £7.50 | |
| Peterborough United FC v AFC Bournemouth 29/09/2021 | £7.50 | |
| Stoke City FC v West Bromwich Albion FC 01/10/2021 | £7.50 | |
| Bristol Rovers FC v Swindon Town FC 02/10/2021 | £7.50 | |
| Newport County AFC v Scunthorpe United FC 02/10/2021 | £7.50 | |
| Port Vale FC v Leyton Orient FC 02/10/2021 | £7.50 | |
| Tranmere Rovers FC v Crawley Town FC 02/10/2021 | £7.50 | |
| Gillingham FC v Wigan Athletic FC 02/10/2021 | £7.50 | |
| Lincoln City FC v Plymouth Argyle FC 02/10/2021 | £7.50 | |
| Sheffield Wednesday FC v Oxford United FC 02/10/2021 | £8.50 |