| Peterborough United FC v Birmingham City FC 18/09/2021 | £7.50 | |
| Preston North End FC v West Bromwich Albion FC 18/09/2021 | £7.50 | |
| Burnley FC v Arsenal FC 18/09/2021 | £7.50 | |
| Manchester City FC v Southampton FC 18/09/2021 | £7.50 | |
| Northampton Town FC v Swindon Town FC 18/09/2021 | £8.50 | |
| Bristol Rovers FC v Leyton Orient FC 18/09/2021 | £7.50 | |
| Newport County AFC v Walsall FC 18/09/2021 | £7.50 | |
| Tranmere Rovers FC v Salford City 18/09/2021 | £7.50 | |
| Sheffield Wednesday FC v Shrewsbury Town FC 18/09/2021 | £7.50 | |
| Gillingham FC v MK Dons (Milton Keynes Dons) 18/09/2021 | £7.50 | |
| Brighton & Hove Albion FC v Leicester City FC 19/09/2021 | £7.50 | |
| West Ham United FC v Manchester United FC 19/09/2021 | £7.50 |