| Nottingham Forest FC v Millwall FC 25/09/2021 | £5.99 | |
| Swansea City FC v Huddersfield Town FC 25/09/2021 | £9.50 | |
| Brentford FC v Liverpool FC 25/09/2021 | £7.50 | |
| Leeds United FC v West Ham United FC 25/09/2021 | £7.50 | |
| Leicester City FC v Burnley FC 25/09/2021 | £7.50 | |
| Hartlepool United v Exeter City FC 25/09/2021 | £7.50 | |
| Rochdale FC v Oldham Athletic FC 25/09/2021 | £7.50 | |
| Burton Albion FC v Lincoln City FC 25/09/2021 | £7.50 | |
| Ipswich Town FC v Sheffield Wednesday FC 25/09/2021 | £7.50 | |
| Morecambe FC v Accrington Stanley FC 25/09/2021 | £8.50 | |
| Plymouth Argyle FC v Doncaster Rovers FC 25/09/2021 | £7.50 | |
| Southampton FC v Wolverhampton Wanderers FC 26/09/2021 | £7.50 |