| Morecambe FC v Preston North End FC 24/08/2021 | £9.50 | |
| Newport County AFC v Southampton FC 25/08/2021 | £8.50 | |
| West Bromwich Albion FC v Arsenal FC 25/08/2021 | £7.50 | |
| Rochdale FC v Colchester United FC 27/08/2021 | £7.50 | |
| Barrow AFC v Bristol Rovers FC 28/08/2021 | £13.50 | |
| Ipswich Town FC v AFC Wimbledon FC 28/08/2021 | £7.50 | |
| Morecambe FC v Sheffield Wednesday FC 28/08/2021 | £9.50 | |
| Plymouth Argyle FC v Fleetwood Town FC 28/08/2021 | £7.50 | |
| Manchester City FC v Arsenal FC 28/08/2021 | £8.50 | |
| Brighton & Hove Albion FC v Everton FC 28/08/2021 | £7.50 | |
| Fulham FC v Stoke City FC 28/08/2021 | £7.50 | |
| Huddersfield Town FC v Reading FC 28/08/2021 | £8.50 |