| AFC Wimbledon FC v Southport 22/01/2011 | View match | |
| Southport v York City FC 29/01/2011 | View match | |
| Southport v Grimsby Town FC 01/02/2011 | View match | |
| Southport v Forest Green Rovers 12/02/2011 | View match | |
| Hayes & Yeading United v Southport 19/02/2011 | View match | |
| Crawley Town FC v Southport 22/02/2011 | View match | |
| Bath City v Southport 26/02/2011 | View match | |
| Southport v Histon 01/03/2011 | View match | |
| Eastbourne Borough v Southport 05/03/2011 | View match | |
| Southport v Cambridge United FC 12/03/2011 | View match | |
| Southport v Barrow AFC 15/03/2011 | View match | |
| Rushden & Diamonds v Southport 19/03/2011 | View match |