| Cambridge United FC v Southport 18/02/2006 | View match | |
| Exeter City FC v Southport 04/03/2006 | View match | |
| Forest Green Rovers v Southport 11/03/2006 | View match | |
| Southport v Hereford United 14/03/2006 | View match | |
| Southport v Altrincham 18/03/2006 | View match | |
| Southport v Accrington Stanley FC 21/03/2006 | View match | |
| Tamworth v Southport 25/03/2006 | View match | |
| Southport v Crawley Town FC 01/04/2006 | View match | |
| FC Halifax Town v Southport 08/04/2006 | View match | |
| Southport v Woking FC 10/04/2006 | View match | |
| Southport v Gravesend & Northfleet 15/04/2006 | View match | |
| Burton Albion FC v Southport 18/04/2006 | View match |