| Southport v Hereford United 14/03/2006 | View match | |
| Southport v Altrincham 18/03/2006 | View match | |
| Southport v Accrington Stanley FC 21/03/2006 | View match | |
| Tamworth v Southport 25/03/2006 | View match | |
| Southport v Crawley Town FC 01/04/2006 | View match | |
| FC Halifax Town v Southport 08/04/2006 | View match | |
| Southport v Woking FC 10/04/2006 | View match | |
| Southport v Gravesend & Northfleet 15/04/2006 | View match | |
| Burton Albion FC v Southport 18/04/2006 | View match | |
| Hereford United v Southport 22/04/2006 | View match | |
| Grays Athletic v Southport 25/04/2006 | View match | |
| Southport v Aldershot Town F.C 29/04/2006 | View match |