| Southport v Kettering Town 09/10/2010 | View match | |
| Grimsby Town FC v Southport 16/10/2010 | View match | |
| Southport v Kidderminister Harriers 29/10/2010 | View match | |
| Southport v Sheffield Wednesday FC 07/11/2010 | View match | |
| Southport v Bath City 13/11/2010 | View match | |
| Newport County AFC v Southport 20/11/2010 | View match | |
| York City FC v Southport 23/11/2010 | View match | |
| Fleetwood Town FC v Southport 28/12/2010 | View match | |
| Barrow AFC v Southport 01/01/2011 | View match | |
| Southport v Gateshead 03/01/2011 | View match | |
| Southport v Newport County AFC 08/01/2011 | View match | |
| Southport v Wrexham FC 18/01/2011 | View match |