| Southport v Tamworth 20/09/2005 | View match | |
| Canvey Island v Southport 24/09/2005 | View match | |
| Scarborough FC v Southport 27/09/2005 | View match | |
| Southport v Cambridge United FC 01/10/2005 | View match | |
| Southport v Forest Green Rovers 07/10/2005 | View match | |
| Altrincham v Southport 15/10/2005 | View match | |
| Southport v Grays Athletic 29/10/2005 | View match | |
| Southport v Woking FC 05/11/2005 | View match | |
| Crawley Town FC v Southport 12/11/2005 | View match | |
| Woking FC v Southport 15/11/2005 | View match | |
| Southport v FC Halifax Town 19/11/2005 | View match | |
| Accrington Stanley FC v Southport 26/11/2005 | View match |