| Southampton FC v Ipswich Town FC 08/11/1980 | £2.00 | |
| Southampton FC v Arsenal FC 11/11/1980 | View match | |
| Manchester City FC v Southampton FC 15/11/1980 | £4.50 | |
| Southampton FC v Leeds United FC 22/11/1980 | £2.50 | |
| Manchester United FC v Southampton FC 29/11/1980 | £2.50 | |
| Southampton FC v Coventry City FC 06/12/1980 | £2.50 | |
| Wolverhampton Wanderers FC v Southampton FC 13/12/1980 | View match | |
| Southampton FC v Crystal Palace FC 20/12/1980 | £2.00 | |
| Tottenham Hotspur FC v Southampton FC 26/12/1980 | £3.50 | |
| Tottenham Hotspur FC v Southampton FC 26/12/1980 | £2.00 | |
| Tottenham Hotspur FC v Southampton FC 26/12/1980 | £2.00 | |
| Tottenham Hotspur FC v Southampton FC 26/12/1980 | £3.00 |