| Southampton FC v Everton FC 14/02/1981 | View match | |
| Everton FC v Southampton FC 17/02/1981 | View match | |
| Southampton FC v West Bromwich Albion FC 21/02/1981 | £2.00 | |
| Brighton & Hove Albion FC v Southampton FC 24/02/1981 | £4.00 | |
| Liverpool FC v Southampton FC 28/02/1981 | View match | |
| Southampton FC v Manchester United FC 07/03/1981 | £2.50 | |
| Southampton FC v Manchester United FC 07/03/1981 | £2.50 | |
| Stoke City FC v Southampton FC 14/03/1981 | View match | |
| Southampton FC v Everton FC 17/03/1981 | £1.00 | |
| Southampton FC v Everton FC 17/03/1981 | £2.00 | |
| Southampton FC v Middlesbrough FC 21/03/1981 | View match | |
| Aston Villa FC v Southampton FC 28/03/1981 | £4.00 |