| Southampton FC v Brighton & Hove Albion FC 06/09/1980 | £3.00 | |
| Southampton FC v Brighton & Hove Albion FC 06/09/1980 | £2.00 | |
| Norwich City FC v Southampton FC 13/09/1980 | View match | |
| Southampton FC v Liverpool FC 20/09/1980 | £2.50 | |
| West Bromwich Albion FC v Southampton FC 27/09/1980 | View match | |
| Everton FC v Southampton FC 04/10/1980 | View match | |
| Southampton FC v Wolverhampton Wanderers FC 07/10/1980 | £1.50 | |
| Southampton FC v Stoke City FC 11/10/1980 | £2.00 | |
| Middlesbrough FC v Southampton FC 18/10/1980 | £5.50 | |
| Crystal Palace FC v Southampton FC 21/10/1980 | View match | |
| Southampton FC v Aston Villa FC 25/10/1980 | View match | |
| Nottingham Forest FC v Southampton FC 01/11/1980 | £4.50 |