| Southampton FC v Stoke City FC 11/10/1980 | £2.00 | |
| Middlesbrough FC v Southampton FC 18/10/1980 | View match | |
| Crystal Palace FC v Southampton FC 21/10/1980 | View match | |
| Southampton FC v Aston Villa FC 25/10/1980 | View match | |
| Nottingham Forest FC v Southampton FC 01/11/1980 | View match | |
| Southampton FC v Ipswich Town FC 08/11/1980 | £2.00 | |
| Southampton FC v Arsenal FC 11/11/1980 | View match | |
| Manchester City FC v Southampton FC 15/11/1980 | £4.50 | |
| Southampton FC v Leeds United FC 22/11/1980 | £2.50 | |
| Manchester United FC v Southampton FC 29/11/1980 | £2.50 | |
| Southampton FC v Coventry City FC 06/12/1980 | £2.50 | |
| Wolverhampton Wanderers FC v Southampton FC 13/12/1980 | View match |