| Carlisle United FC v Port Vale FC 08/02/2022 | View match | |
| Port Vale FC v Northampton Town FC 12/02/2022 | View match | |
| Tranmere Rovers FC v Port Vale FC 19/02/2022 | £7.50 | |
| Rochdale FC v Port Vale FC 22/02/2022 | View match | |
| Port Vale FC v Stevenage Borough FC 26/02/2022 | View match | |
| Harrogate Town v Port Vale FC 01/03/2022 | View match | |
| Colchester United FC v Port Vale FC 05/03/2022 | View match | |
| Port Vale FC v Crawley Town FC 12/03/2022 | View match | |
| Port Vale FC v Mansfield Town FC 15/03/2022 | View match | |
| Bradford City FC v Port Vale FC 19/03/2022 | View match | |
| Port Vale FC v Exeter City FC 22/03/2022 | View match | |
| Port Vale FC v Sutton United 26/03/2022 | View match |