| Port Vale FC v Hartlepool United 27/11/2021 | View match | |
| Rotherham United FC v Port Vale FC 30/11/2021 | View match | |
| Burton Albion FC v Port Vale FC 04/12/2021 | View match | |
| Bristol Rovers FC v Port Vale FC 07/12/2021 | View match | |
| Newport County AFC v Port Vale FC 11/12/2021 | £7.50 | |
| Rochdale FC v Port Vale FC 29/12/2021 | £7.50 | |
| Port Vale FC v Brentford FC 08/01/2022 | View match | |
| Port Vale FC v Swindon Town FC 15/01/2022 | £7.50 | |
| Port Vale FC v Salford City 18/01/2022 | View match | |
| Leyton Orient FC v Port Vale FC 22/01/2022 | View match | |
| Port Vale FC v Scunthorpe United FC 29/01/2022 | View match | |
| Port Vale FC v Forest Green Rovers 01/02/2022 | View match |