| Port Vale FC v Mansfield Town FC 08/05/2021 | View match | |
| Northampton Town FC v Port Vale FC 07/08/2021 | £8.50 | |
| Port Vale FC v Sunderland FC 10/08/2021 | View match | |
| Port Vale FC v Tranmere Rovers FC 14/08/2021 | View match | |
| Port Vale FC v Carlisle United FC 17/08/2021 | View match | |
| Stevenage Borough FC v Port Vale FC 21/08/2021 | View match | |
| Forest Green Rovers v Port Vale FC 28/08/2021 | View match | |
| Bolton Wanderers FC v Port Vale FC 31/08/2021 | View match | |
| Port Vale FC v Rochdale FC 04/09/2021 | View match | |
| Swindon Town FC v Port Vale FC 11/09/2021 | View match | |
| Port Vale FC v Harrogate Town 18/09/2021 | View match | |
| Scunthorpe United FC v Port Vale FC 25/09/2021 | View match |