| Forest Green Rovers v Port Vale FC 28/08/2021 | View match | |
| Bolton Wanderers FC v Port Vale FC 31/08/2021 | View match | |
| Port Vale FC v Rochdale FC 04/09/2021 | View match | |
| Swindon Town FC v Port Vale FC 11/09/2021 | View match | |
| Port Vale FC v Harrogate Town 18/09/2021 | View match | |
| Scunthorpe United FC v Port Vale FC 25/09/2021 | View match | |
| Port Vale FC v Leyton Orient FC 02/10/2021 | £7.50 | |
| Port Vale FC v Rochdale FC 05/10/2021 | View match | |
| Sutton United v Port Vale FC 09/10/2021 | View match | |
| Port Vale FC v Barrow AFC 16/10/2021 | View match | |
| Mansfield Town FC v Port Vale FC 19/10/2021 | View match | |
| Port Vale FC v Colchester United FC 23/10/2021 | View match |