| Port Vale FC v Leyton Orient FC 02/10/2021 | £7.50 | |
| Port Vale FC v Rochdale FC 05/10/2021 | View match | |
| Sutton United v Port Vale FC 09/10/2021 | View match | |
| Port Vale FC v Barrow AFC 16/10/2021 | View match | |
| Mansfield Town FC v Port Vale FC 19/10/2021 | View match | |
| Port Vale FC v Colchester United FC 23/10/2021 | View match | |
| Crawley Town FC v Port Vale FC 30/10/2021 | View match | |
| Port Vale FC v Accrington Stanley FC 06/11/2021 | View match | |
| Port Vale FC v Liverpool (U21`s) 09/11/2021 | View match | |
| Port Vale FC v Bradford City FC 13/11/2021 | View match | |
| Oldham Athletic FC v Port Vale FC 20/11/2021 | View match | |
| Port Vale FC v Walsall FC 23/11/2021 | View match |