| East Fife FC v Airdrieonians (Old) 02/04/2022 | View match | |
| Queens Park FC v East Fife FC 09/04/2022 | View match | |
| East Fife FC v Falkirk FC 16/04/2022 | View match | |
| Peterhead v East Fife FC 23/04/2022 | View match | |
| East Fife FC v Cove Rangers 30/04/2022 | View match | |
| Elgin City FC v East Fife FC 30/07/2022 | View match | |
| East Fife FC v Bonnyrigg Rose Athletic 06/08/2022 | View match | |
| Albion Rovers FC v East Fife FC 13/08/2022 | View match | |
| East Fife FC v Forfar Athletic FC 20/08/2022 | View match | |
| Stranraer v East Fife FC 27/08/2022 | View match | |
| East Fife FC v Dumbarton 03/09/2022 | View match | |
| Annan Athletic FC v East Fife FC 17/09/2022 | View match |