| East Fife FC v Dumbarton 24/04/2021 | View match | |
| East Fife FC v Peterhead 29/04/2021 | View match | |
| Forfar Athletic FC v East Fife FC 04/05/2021 | View match | |
| Clyde v East Fife FC 06/05/2021 | View match | |
| East Fife FC v Queens Park FC 31/07/2021 | View match | |
| Alloa Athletic FC v East Fife FC 07/08/2021 | View match | |
| Cove Rangers v East Fife FC 14/08/2021 | View match | |
| East Fife FC v Montrose FC 21/08/2021 | View match | |
| East Fife FC v Peterhead 28/08/2021 | View match | |
| Dumbarton v East Fife FC 11/09/2021 | View match | |
| Airdrieonians (Old) v East Fife FC 18/09/2021 | View match | |
| East Fife FC v Clyde 25/09/2021 | View match |