| East Fife FC v Falkirk FC 02/01/2021 | View match | |
| East Fife FC v Tranent (Juniors) 09/01/2021 | View match | |
| Clyde v East Fife FC 20/03/2021 | View match | |
| East Fife FC v Cove Rangers 27/03/2021 | View match | |
| Montrose FC v East Fife FC 30/03/2021 | View match | |
| East Fife FC v Clyde 01/04/2021 | View match | |
| East Fife FC v Greenock Morton 03/04/2021 | View match | |
| East Fife FC v Partick Thistle FC 06/04/2021 | View match | |
| Dumbarton v East Fife FC 08/04/2021 | View match | |
| Forfar Athletic FC v East Fife FC 10/04/2021 | View match | |
| East Fife FC v Peterhead 17/04/2021 | View match | |
| Airdrieonians (Old) v East Fife FC 20/04/2021 | View match |