| Airdrieonians (Old) v East Fife FC 08/01/2022 | View match | |
| Dumbarton v East Fife FC 15/01/2022 | View match | |
| East Fife FC v Falkirk FC 22/01/2022 | View match | |
| East Fife FC v Peterhead 29/01/2022 | View match | |
| East Fife FC v Clyde 05/02/2022 | View match | |
| Alloa Athletic FC v East Fife FC 12/02/2022 | View match | |
| East Fife FC v Queens Park FC 19/02/2022 | View match | |
| Falkirk FC v East Fife FC 26/02/2022 | View match | |
| Montrose FC v East Fife FC 05/03/2022 | View match | |
| East Fife FC v Dumbarton 12/03/2022 | View match | |
| Clyde v East Fife FC 19/03/2022 | View match | |
| East Fife FC v Alloa Athletic FC 26/03/2022 | View match |