| Falkirk FC v East Fife FC 02/10/2021 | View match | |
| East Fife FC v Cove Rangers 16/10/2021 | View match | |
| Montrose FC v East Fife FC 23/10/2021 | View match | |
| East Fife FC v Dumbarton 30/10/2021 | View match | |
| Queens Park FC v East Fife FC 06/11/2021 | View match | |
| East Fife FC v Airdrieonians (Old) 13/11/2021 | View match | |
| Clyde v East Fife FC 20/11/2021 | View match | |
| Banks O`Dee v East Fife FC 27/11/2021 | View match | |
| East Fife FC v Alloa Athletic FC 04/12/2021 | View match | |
| Peterhead v East Fife FC 11/12/2021 | View match | |
| Cove Rangers v East Fife FC 26/12/2021 | View match | |
| East Fife FC v Montrose FC 02/01/2022 | View match |