| Southampton FC v Shrewsbury Town FC 19/01/2021 | View match | |
| Southampton FC v Arsenal FC 23/01/2021 | View match | |
| Southampton FC v Arsenal FC 26/01/2021 | £7.50 | |
| Southampton FC v Aston Villa FC 30/01/2021 | View match | |
| Manchester United FC v Southampton FC 02/02/2021 | £7.50 | |
| Newcastle United FC v Southampton FC 06/02/2021 | View match | |
| Wolverhampton Wanderers FC v Southampton FC 10/02/2021 | £7.50 | |
| Southampton FC v Wolverhampton Wanderers FC 14/02/2021 | £7.50 | |
| Southampton FC v Chelsea FC 20/02/2021 | £7.50 | |
| Leeds United FC v Southampton FC 23/02/2021 | £7.50 | |
| Everton FC v Southampton FC 01/03/2021 | £7.50 | |
| Sheffield United FC v Southampton FC 06/03/2021 | View match |