| Southampton FC v Newcastle United FC 02/01/2022 | View match | |
| Swansea City FC v Southampton FC 08/01/2022 | £8.50 | |
| Southampton FC v Brentford FC 11/01/2022 | View match | |
| Wolverhampton Wanderers FC v Southampton FC 15/01/2022 | View match | |
| Southampton FC v Manchester City FC 22/01/2022 | View match | |
| Southampton FC v Coventry City FC 05/02/2022 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 09/02/2022 | View match | |
| Manchester United FC v Southampton FC 12/02/2022 | £5.99 | |
| Southampton FC v Everton FC 19/02/2022 | £7.50 | |
| Southampton FC v Norwich City FC 25/02/2022 | £8.50 | |
| Southampton FC v West Ham United FC 02/03/2022 | £7.50 | |
| Aston Villa FC v Southampton FC 05/03/2022 | View match |