| Tottenham Hotspur FC v Southampton FC 06/08/2022 | £7.00 | |
| Southampton FC v Leeds United FC 13/08/2022 | £8.00 | |
| Leicester City FC v Southampton FC 20/08/2022 | View match | |
| Cambridge United FC v Southampton FC 23/08/2022 | £8.00 | |
| Southampton FC v Manchester United FC 27/08/2022 | £8.00 | |
| Southampton FC v Chelsea FC 30/08/2022 | View match | |
| Wolverhampton Wanderers FC v Southampton FC 03/09/2022 | View match | |
| Aston Villa FC v Southampton FC 16/09/2022 | View match | |
| Southampton FC v Everton FC 01/10/2022 | View match | |
| Manchester City FC v Southampton FC 08/10/2022 | View match | |
| Southampton FC v West Ham United FC 16/10/2022 | View match | |
| AFC Bournemouth v Southampton FC 19/10/2022 | View match |