| West Bromwich Albion FC v Southampton FC 12/04/2021 | View match | |
| Leicester City FC v Southampton FC 18/04/2021 | View match | |
| Tottenham Hotspur FC v Southampton FC 21/04/2021 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 21/04/2021 | £8.00 | |
| Southampton FC v Leicester City FC 30/04/2021 | View match | |
| Liverpool FC v Southampton FC 08/05/2021 | View match | |
| Southampton FC v Crystal Palace FC 11/05/2021 | View match | |
| Southampton FC v Fulham FC 15/05/2021 | View match | |
| Southampton FC v Leeds United FC 18/05/2021 | £7.50 | |
| West Ham United FC v Southampton FC 23/05/2021 | View match | |
| Cardiff City FC v Southampton FC 27/07/2021 | £5.00 | |
| Swansea City FC v Southampton FC 31/07/2021 | £14.99 |