| Hapoel Beer - Sheva v Southampton FC 29/09/2016 | View match | |
| Leicester City FC v Southampton FC 02/10/2016 | View match | |
| Southampton FC v Burnley FC 16/10/2016 | View match | |
| Manchester City FC v Southampton FC 23/10/2016 | View match | |
| Southampton FC v Sunderland FC 26/10/2016 | View match | |
| Southampton FC v Chelsea FC 30/10/2016 | £17.00 | |
| Southampton FC v Internazionale/Inter Milan 03/11/2016 | £2.50 | |
| Hull City FC v Southampton FC 06/11/2016 | View match | |
| Southampton FC v Liverpool FC 19/11/2016 | £6.50 | |
| Sparta Prague v Southampton FC 24/11/2016 | View match | |
| Southampton FC v Everton FC 27/11/2016 | £6.50 | |
| Arsenal FC v Southampton FC 30/11/2016 | £7.50 |