| Chelsea FC v Lille OSC 22/02/2022 | £9.50 | |
| Burnley FC v Tottenham Hotspur FC 23/02/2022 | £7.50 | |
| Huddersfield Town FC v Cardiff City FC 23/02/2022 | £7.50 | |
| Arsenal FC v Wolverhampton Wanderers FC 24/02/2022 | £7.50 | |
| Southampton FC v Norwich City FC 25/02/2022 | £8.50 | |
| Crystal Palace FC v Burnley FC 26/02/2022 | £8.50 | |
| Everton FC v Manchester City FC 26/02/2022 | £11.50 | |
| Manchester United FC v Watford FC 26/02/2022 | £7.50 | |
| Birmingham City FC v Huddersfield Town FC 26/02/2022 | £7.50 | |
| AFC Bournemouth v Stoke City FC 26/02/2022 | £7.50 | |
| Luton Town FC v Derby County FC 26/02/2022 | £7.50 | |
| Barrow AFC v Harrogate Town 26/02/2022 | £8.50 |