| Mansfield Town FC v Swindon Town FC 11/01/2022 | £7.50 | |
| Liverpool FC v Arsenal FC 13/01/2022 | £7.50 | |
| AFC Wimbledon FC v Morecambe FC 15/01/2022 | £7.50 | |
| Cheltenham Town FC v Charlton Athletic FC 15/01/2022 | £7.50 | |
| Doncaster Rovers FC v Wigan Athletic FC 15/01/2022 | £7.50 | |
| Gillingham FC v Burton Albion FC 15/01/2022 | £7.50 | |
| Sheffield Wednesday FC v Plymouth Argyle FC 15/01/2022 | £9.50 | |
| Newport County AFC v Harrogate Town 15/01/2022 | £7.50 | |
| Port Vale FC v Swindon Town FC 15/01/2022 | £7.50 | |
| Cardiff City FC v Blackburn Rovers FC 15/01/2022 | £7.00 | |
| Huddersfield Town FC v Swansea City FC 15/01/2022 | £8.50 | |
| Huddersfield Town FC v Swansea City FC 15/01/2022 | £5.00 |