| Southampton FC v Brighton & Hove Albion FC 04/12/2021 | £6.00 | |
| Wolverhampton Wanderers FC v Liverpool FC 04/12/2021 | £7.50 | |
| Cardiff City FC v Sheffield United FC 04/12/2021 | £7.00 | |
| Coventry City FC v West Bromwich Albion FC 04/12/2021 | £7.50 | |
| AFC Wimbledon FC v Cheltenham Town FC 04/12/2021 | £7.50 | |
| Rochdale FC v Plymouth Argyle FC 05/12/2021 | £7.50 | |
| Manchester United FC v Crystal Palace FC 05/12/2021 | £7.50 | |
| Everton FC v Arsenal FC 06/12/2021 | £7.50 | |
| Cheltenham Town FC v Cambridge United FC 07/12/2021 | £7.50 | |
| Doncaster Rovers FC v Oxford United FC 07/12/2021 | £6.99 | |
| Portsmouth FC v Sheffield Wednesday FC 07/12/2021 | £7.50 | |
| Harrogate Town v Forest Green Rovers 07/12/2021 | £7.50 |