| Newport County AFC v Sutton United 07/12/2021 | £7.50 | |
| Manchester United FC v BSC Young Boy`s Bern 08/12/2021 | £7.50 | |
| Barrow AFC v Salford City 08/12/2021 | £9.50 | |
| Brentford FC v Watford FC 10/12/2021 | £7.50 | |
| Arsenal FC v Southampton FC 11/12/2021 | £7.50 | |
| Liverpool FC v Aston Villa FC 11/12/2021 | £9.50 | |
| Manchester City FC v Wolverhampton Wanderers FC 11/12/2021 | £7.50 | |
| Norwich City FC v Manchester United FC 11/12/2021 | £7.50 | |
| AFC Bournemouth v Blackburn Rovers FC 11/12/2021 | £6.99 | |
| Huddersfield Town FC v Coventry City FC 11/12/2021 | £8.50 | |
| Luton Town FC v Fulham FC 11/12/2021 | £7.50 | |
| Swansea City FC v Nottingham Forest FC 11/12/2021 | £10.50 |