| Oldham Athletic FC v Southport 19/03/1949 | View match | |
| Southport v Accrington Stanley (1891) 26/03/1949 | View match | |
| Rotherham United FC v Southport 02/04/1949 | View match | |
| Southport v Hull City FC 09/04/1949 | View match | |
| Chester City FC v Southport 15/04/1949 | View match | |
| Doncaster Rovers FC v Southport 16/04/1949 | View match | |
| Southport v Chester City FC 18/04/1949 | View match | |
| Southport v Bradford City FC 23/04/1949 | View match | |
| Southport v Halifax Town A.F.C 26/04/1949 | View match | |
| Halifax Town A.F.C v Southport 30/04/1949 | View match | |
| Southport v Stockport County FC 02/05/1949 | View match | |
| Southport v Wrexham FC 07/05/1949 | View match |