| Boston United v Southport 06/08/2022 | View match | |
| Southport v Peterborough Sports 13/08/2022 | View match | |
| Southport v Darlington FC 16/08/2022 | View match | |
| Alfreton Town v Southport 20/08/2022 | View match | |
| Southport v AFC Telford Utd 27/08/2022 | View match | |
| AFC Fylde v Southport 29/08/2022 | View match | |
| Banbury United v Southport 03/09/2022 | View match | |
| Chester FC v Southport 13/09/2022 | View match | |
| Southport v Leamington 24/09/2022 | View match | |
| Southport v Bradford Park Avenue 01/10/2022 | View match | |
| Gloucester City v Southport 08/10/2022 | View match | |
| Farsley Celtic v Southport 15/10/2022 | View match |