| Southport v Oldham Athletic FC 04/04/1959 | View match | |
| Barrow v Southport 11/04/1959 | View match | |
| Southport v Coventry City FC 14/04/1959 | View match | |
| Southport v Carlisle United FC 18/04/1959 | View match | |
| Oldham Athletic FC v Southport 20/04/1959 | View match | |
| Wigan Athletic FC v Southport 20/04/1959 | View match | |
| Gillingham FC v Southport 25/04/1959 | View match | |
| Southport v Exeter City FC 28/04/1959 | View match | |
| Southport v Rochdale FC 22/08/1959 | View match | |
| Workington v Southport 27/08/1959 | View match | |
| Gateshead v Southport 29/08/1959 | View match | |
| Southport v Workington 01/09/1959 | View match |