| Southport v Gillingham FC 24/01/1959 | View match | |
| Southport v Torquay United FC 31/01/1959 | View match | |
| Crewe Alexandra FC v Southport 07/02/1959 | View match | |
| Southport v Northampton Town FC 14/02/1959 | View match | |
| Workington v Southport 21/02/1959 | View match | |
| Darlington FC v Southport 28/02/1959 | View match | |
| Southport v Walsall FC 07/03/1959 | View match | |
| Millwall FC v Southport 14/03/1959 | View match | |
| Southport v Aldershot F.C 21/03/1959 | View match | |
| Southport v Chester City FC 27/03/1959 | View match | |
| Gateshead v Southport 28/03/1959 | View match | |
| Chester City FC v Southport 30/03/1959 | View match |