| Chelsea FC v Southampton FC 26/10/2021 | £7.50 | |
| Southampton FC v Aston Villa FC 05/11/2021 | £7.50 | |
| Southampton FC v Brighton & Hove Albion FC 04/12/2021 | £7.50 | |
| Southampton FC v Brighton & Hove Albion FC 04/12/2021 | £6.00 | |
| Arsenal FC v Southampton FC 11/12/2021 | £5.50 | |
| Arsenal FC v Southampton FC 11/12/2021 | £7.50 | |
| Crystal Palace FC v Southampton FC 15/12/2021 | £7.50 | |
| Southampton FC v Tottenham Hotspur FC 28/12/2021 | £7.50 | |
| Swansea City FC v Southampton FC 08/01/2022 | £8.50 | |
| Southampton FC v Coventry City FC 05/02/2022 | £7.50 | |
| Manchester United FC v Southampton FC 12/02/2022 | £5.99 | |
| Southampton FC v Everton FC 19/02/2022 | £7.50 |