| Arsenal FC v Southampton FC 08/04/2018 | £4.50 | |
| Leicester City FC v Southampton FC 19/04/2018 | £6.50 | |
| Chelsea FC v Southampton FC 22/04/2018 | £7.00 | |
| Brighton & Hove Albion FC v Southampton FC 28/08/2018 | £8.50 | |
| Crystal Palace FC v Southampton FC 01/09/2018 | £6.50 | |
| Southampton FC v Brighton & Hove Albion FC 17/09/2018 | £6.50 | |
| Southampton FC v Brighton & Hove Albion FC 17/09/2018 | £5.00 | |
| Southampton FC v Chelsea FC 07/10/2018 | £6.50 | |
| Manchester City FC v Southampton FC 04/11/2018 | £7.50 | |
| Tottenham Hotspur FC v Southampton FC 05/12/2018 | £6.50 | |
| Tottenham Hotspur FC v Southampton FC 05/12/2018 | £7.50 | |
| Cardiff City FC v Southampton FC 08/12/2018 | £7.00 |