| Arsenal FC v Southampton FC 11/12/2021 | £7.50 | |
| Crystal Palace FC v Southampton FC 15/12/2021 | £7.50 | |
| Southampton FC v Tottenham Hotspur FC 28/12/2021 | £7.50 | |
| Swansea City FC v Southampton FC 08/01/2022 | £8.50 | |
| Southampton FC v Coventry City FC 05/02/2022 | £7.50 | |
| Manchester United FC v Southampton FC 12/02/2022 | £5.99 | |
| Southampton FC v Everton FC 19/02/2022 | £7.50 | |
| Southampton FC v Norwich City FC 25/02/2022 | £8.50 | |
| Southampton FC v West Ham United FC 02/03/2022 | £7.50 | |
| Southampton FC v Newcastle United FC 10/03/2022 | £7.50 | |
| Southampton FC v Manchester City FC 20/03/2022 | £7.50 | |
| Leeds United FC v Southampton FC 02/04/2022 | £7.50 |