| Southampton FC v West Bromwich Albion FC 04/10/2020 | £7.50 | |
| Chelsea FC v Southampton FC 17/10/2020 | £7.50 | |
| Southampton FC v Newcastle United FC 06/11/2020 | £7.50 | |
| Wolverhampton Wanderers FC v Southampton FC 23/11/2020 | £7.50 | |
| Southampton FC v Manchester United FC 29/11/2020 | £7.50 | |
| Southampton FC v Manchester City FC 19/12/2020 | £7.50 | |
| Fulham FC v Southampton FC 26/12/2020 | £7.50 | |
| Southampton FC v Liverpool FC 04/01/2021 | £7.50 | |
| Leicester City FC v Southampton FC 16/01/2021 | £9.99 | |
| Southampton FC v Arsenal FC 26/01/2021 | £7.50 | |
| Manchester United FC v Southampton FC 02/02/2021 | £7.50 | |
| Wolverhampton Wanderers FC v Southampton FC 10/02/2021 | £7.50 |