| Southampton FC v Coventry City FC 18/02/1950 | View match | |
| Tottenham Hotspur FC v Southampton FC 25/02/1950 | View match | |
| Southampton FC v Cardiff City FC 04/03/1950 | View match | |
| Blackburn Rovers FC v Southampton FC 11/03/1950 | View match | |
| Southampton FC v Brentford FC 18/03/1950 | £25.00 | |
| Hull City FC v Southampton FC 25/03/1950 | View match | |
| Southampton FC v Chesterfield FC 01/04/1950 | £20.00 | |
| Bradford Park Avenue v Southampton FC 08/04/1950 | View match | |
| Southampton FC v Sheffield United FC 10/04/1950 | £20.00 | |
| Southampton FC v Sheffield Wednesday FC 15/04/1950 | £20.00 | |
| Cardiff City FC v Southampton FC 17/04/1950 | View match | |
| Plymouth Argyle FC v Southampton FC 22/04/1950 | View match |