| Grimsby Town FC v Southampton FC 15/04/1949 | View match | |
| Bury FC v Southampton FC 16/04/1949 | View match | |
| Southampton FC v Grimsby Town FC 18/04/1949 | View match | |
| Southampton FC v West Bromwich Albion FC 23/04/1949 | View match | |
| Chesterfield FC v Southampton FC 30/04/1949 | View match | |
| Southampton FC v Grimsby Town FC 20/08/1949 | View match | |
| Barnsley FC v Southampton FC 24/08/1949 | View match | |
| Queens Park Rangers FC v Southampton FC 27/08/1949 | View match | |
| Southampton FC v Barnsley FC 31/08/1949 | £25.00 | |
| Southampton FC v Preston North End FC 03/09/1949 | £25.00 | |
| West Ham United FC v Southampton FC 05/09/1949 | View match | |
| Swansea Town v Southampton FC 10/09/1949 | View match |