| Southampton FC v Leeds United FC 17/09/1949 | View match | |
| Bury FC v Southampton FC 24/09/1949 | View match | |
| Coventry City FC v Southampton FC 01/10/1949 | View match | |
| Southampton FC v Tottenham Hotspur FC 08/10/1949 | £18.00 | |
| Southampton FC v Blackburn Rovers FC 22/10/1949 | £20.00 | |
| Brentford FC v Southampton FC 29/10/1949 | View match | |
| Southampton FC v Hull City FC 05/11/1949 | £25.00 | |
| Sheffield Wednesday FC v Southampton FC 12/11/1949 | View match | |
| Southampton FC v Plymouth Argyle FC 19/11/1949 | View match | |
| Chesterfield FC v Southampton FC 26/11/1949 | View match | |
| Southampton FC v Bradford Park Avenue 03/12/1949 | £25.00 | |
| Leicester City FC v Southampton FC 10/12/1949 | View match |