| Southampton FC v Bolton Wanderers FC 01/01/1966 | View match | |
| Huddersfield Town FC v Southampton FC 08/01/1966 | View match | |
| Hull City FC v Southampton FC 22/01/1966 | View match | |
| Southampton FC v Derby County FC 29/01/1966 | View match | |
| Portsmouth FC v Southampton FC 05/02/1966 | View match | |
| Southampton FC v Arsenal FC 12/02/1966 | View match | |
| Bury FC v Southampton FC 19/02/1966 | £7.00 | |
| Southampton FC v Norwich City FC 26/02/1966 | £7.50 | |
| Southampton FC v Birmingham City FC 05/03/1966 | View match | |
| Wolverhampton Wanderers FC v Southampton FC 12/03/1966 | View match | |
| Southampton FC v Rotherham United FC 19/03/1966 | £9.00 | |
| Southampton FC v Middlesbrough FC 02/04/1966 | View match |