| Clydebank FC (Old) v Aberdeen FC 21/09/1921 | View match | |
| Motherwell FC v Dundee 21/09/1921 | View match | |
| Armadale v Bathgate 21/09/1921 | View match | |
| Raith Rovers FC v Kilmarnock FC 24/09/1921 | View match | |
| Ayr United FC v Airdrieonians (Old) 24/09/1921 | View match | |
| Third Lanark v Clydebank FC (Old) 24/09/1921 | View match | |
| Johnstone v Cowdenbeath FC 24/09/1921 | View match | |
| Boness United v Alloa Athletic FC 24/09/1921 | View match | |
| Arbroath FC v Broxburn United 24/09/1921 | View match | |
| Stenhousemuir FC v Kings Park 24/09/1921 | View match | |
| Hibernian FC v Falkirk FC 24/09/1921 | View match | |
| Clyde v Morton FC 24/09/1921 | View match |