| Watford FC v Brentford FC 17/09/1921 | View match | |
| Southend United FC v Swansea Town 17/09/1921 | View match | |
| Birmingham v Everton FC 17/09/1921 | View match | |
| The Wednesday v Notts County FC 17/09/1921 | View match | |
| Chesterfield FC v Darlington FC 17/09/1921 | View match | |
| Crewe Alexandra FC v Accrington Stanley (1891) 17/09/1921 | View match | |
| Armadale v Dundee United FC 17/09/1921 | View match | |
| East Fife FC v East Stirlingshire FC 17/09/1921 | View match | |
| Cowdenbeath FC v Bathgate 17/09/1921 | View match | |
| Falkirk FC v Albion Rovers FC 17/09/1921 | View match | |
| Motherwell FC v Hibernian FC 17/09/1921 | View match | |
| Morton FC v Queens Park FC 17/09/1921 | View match |