| Wigan Borough v Stockport County FC 10/09/1921 | View match | |
| Durham City v Barrow 10/09/1921 | View match | |
| Stalybridge Celtic v Grimsby Town FC 10/09/1921 | View match | |
| Dumbarton v Third Lanark 10/09/1921 | View match | |
| Nelson v Stalybridge Celtic 12/09/1921 | View match | |
| Clapton Orient v Port Vale FC 12/09/1921 | View match | |
| Swansea Town v Brighton & Hove Albion FC 12/09/1921 | View match | |
| Aston Villa FC v Blackburn Rovers FC 12/09/1921 | View match | |
| Newport County v Southend United FC 12/09/1921 | View match | |
| Clyde v Motherwell FC 13/09/1921 | View match | |
| St Mirren FC v Hibernian FC 13/09/1921 | View match | |
| Aberdeen FC v Falkirk FC 14/09/1921 | View match |