| Swindon Town FC v Leyton Orient FC 16/08/2022 | £8.00 | |
| Barrow AFC v Leyton Orient FC 24/09/2022 | £8.00 | |
| Doncaster Rovers FC v Leyton Orient FC 08/10/2022 | £8.00 | |
| Carlisle United FC v Leyton Orient FC 22/10/2022 | £8.00 | |
| Harrogate Town v Leyton Orient FC 12/11/2022 | £8.00 | |
| Newport County AFC v Leyton Orient FC 30/12/2022 | £8.00 | |
| Northampton Town FC v Leyton Orient FC 02/01/2023 | £8.00 | |
| Stevenage Borough FC v Leyton Orient FC 21/01/2023 | £8.00 | |
| Tranmere Rovers FC v Leyton Orient FC 28/01/2023 | £8.00 | |
| Walsall FC v Leyton Orient FC 11/02/2023 | £8.00 | |
| Leyton Orient FC v Rochdale FC 14/02/2023 | £9.50 | |
| Grimsby Town FC v Leyton Orient FC 25/02/2023 | £8.00 |