| Mansfield Town FC v Leyton Orient FC 29/01/2022 | £7.50 | |
| Exeter City FC v Leyton Orient FC 08/02/2022 | £7.50 | |
| Hartlepool United v Leyton Orient FC 12/03/2022 | £8.50 | |
| Harrogate Town v Leyton Orient FC 22/03/2022 | £7.50 | |
| Walsall FC v Leyton Orient FC 02/04/2022 | £7.50 | |
| Crawley Town FC v Leyton Orient FC 06/08/2022 | £8.00 | |
| Swindon Town FC v Leyton Orient FC 16/08/2022 | £8.00 | |
| Barrow AFC v Leyton Orient FC 24/09/2022 | £8.00 | |
| Doncaster Rovers FC v Leyton Orient FC 08/10/2022 | £8.00 | |
| Carlisle United FC v Leyton Orient FC 22/10/2022 | £8.00 | |
| Harrogate Town v Leyton Orient FC 12/11/2022 | £8.00 | |
| Newport County AFC v Leyton Orient FC 30/12/2022 | £8.00 |