| Salford City v Leyton Orient FC 07/08/2021 | £7.50 | |
| Leyton Orient FC v Queens Park Rangers FC 11/08/2021 | £7.50 | |
| Carlisle United FC v Leyton Orient FC 21/08/2021 | £7.00 | |
| Newport County AFC v Leyton Orient FC 04/09/2021 | £7.50 | |
| Bristol Rovers FC v Leyton Orient FC 18/09/2021 | £7.50 | |
| Port Vale FC v Leyton Orient FC 02/10/2021 | £7.50 | |
| Barrow AFC v Leyton Orient FC 09/10/2021 | £8.50 | |
| Stevenage Borough FC v Leyton Orient FC 23/10/2021 | £7.50 | |
| Rochdale FC v Leyton Orient FC 13/11/2021 | £7.50 | |
| Northampton Town FC v Leyton Orient FC 27/11/2021 | £7.50 | |
| Tranmere Rovers FC v Leyton Orient FC 18/12/2021 | £7.50 | |
| Colchester United FC v Leyton Orient FC 26/12/2021 | £7.50 |