| Wrexham FC v Wealdstone 20/11/2021 | View match | |
| FC Halifax Town v Wrexham FC 23/11/2021 | View match | |
| Wrexham FC v Bromley FC 27/11/2021 | View match | |
| Wrexham FC v Yeovil Town FC 30/11/2021 | View match | |
| Dover Athletic FC v Wrexham FC 04/12/2021 | View match | |
| Wrexham FC v Weymouth 11/12/2021 | View match | |
| Altrincham v Wrexham FC 28/12/2021 | View match | |
| Notts County FC v Wrexham FC 02/01/2022 | View match | |
| Yeovil Town FC v Wrexham FC 22/01/2022 | View match | |
| Wrexham FC v Grimsby Town FC 25/01/2022 | View match | |
| Wrexham FC v Maidenhead United 29/01/2022 | View match | |
| Torquay United FC v Wrexham FC 05/02/2022 | View match |