| Southend United FC v Wrexham FC 04/09/2021 | View match | |
| Wrexham FC v Woking FC 11/09/2021 | View match | |
| Grimsby Town FC v Wrexham FC 14/09/2021 | View match | |
| Wrexham FC v Dagenham & Redbridge 18/09/2021 | View match | |
| Stockport County FC v Wrexham FC 25/09/2021 | View match | |
| Wrexham FC v Chesterfield FC 05/10/2021 | View match | |
| Barnet FC v Wrexham FC 23/10/2021 | View match | |
| Maidenhead United v Wrexham FC 26/10/2021 | View match | |
| Wrexham FC v Torquay United FC 30/10/2021 | View match | |
| Harrogate Town v Wrexham FC 06/11/2021 | View match | |
| Aldershot Town F.C v Wrexham FC 09/11/2021 | View match | |
| Kings Lynn Town v Wrexham FC 13/11/2021 | View match |