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| Harrogate Town v Tranmere Rovers FC 19/10/2021 | View match | |
| Tranmere Rovers FC v Northampton Town FC 23/10/2021 | £7.50 | |
| Mansfield Town FC v Tranmere Rovers FC 30/10/2021 | View match | |
| Crawley Town FC v Tranmere Rovers FC 06/11/2021 | View match | |
| Tranmere Rovers FC v Oldham Athletic FC 09/11/2021 | View match | |
| Tranmere Rovers FC v Sutton United 13/11/2021 | £7.50 | |
| Bristol Rovers FC v Tranmere Rovers FC 20/11/2021 | View match | |
| Tranmere Rovers FC v Bradford City FC 23/11/2021 | £7.50 | |
| Leyton Orient FC v Tranmere Rovers FC 04/12/2021 | View match | |
| Oldham Athletic FC v Tranmere Rovers FC 07/12/2021 | View match | |
| Exeter City FC v Tranmere Rovers FC 11/12/2021 | View match |